MGP Database

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MGP000940

Ontology/Pathway Information

Entrez Gene ID1977
Gene Nameeukaryotic translation initiation factor 4E
Gene Symbol EIF4E
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0033391 IEA:EnsemblCchromatoid body
GO:0005737 IDA:HPACcytoplasm
GO:0000932 IDA:MGICcytoplasmic mRNA processing body
GO:0010494 IDA:UniProtKBCcytoplasmic stress granule
GO:0005829 TAS:ReactomeCcytosol
GO:0016281 IDA:UniProtKBCeukaryotic translation initiation factor 4F complex
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005845 IDA:UniProtKBCmRNA cap binding complex
GO:0016442 IDA:MGICRISC complex
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0000339 TAS:ProtIncFRNA cap binding
GO:0003743 IDA:UniProtKBFtranslation initiation factor activity
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0000082 IMP:UniProtKBPG1/S transition of mitotic cell cycle
GO:0010467 TAS:ReactomePgene expression
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0030324 IEA:EnsemblPlung development
GO:0006406 TAS:ReactomePmRNA export from nucleus
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0000288 TAS:ReactomePnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 TAS:ReactomePnuclear-transcribed mRNA poly(A) tail shortening
GO:0045931 IMP:UniProtKBPpositive regulation of mitotic cell cycle
GO:0006417 IDA:UniProtKBPregulation of translation
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0006412 TAS:ReactomePtranslation
GO:0006413 TAS:ReactomePtranslational initiation
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1258Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
REACT_115676Antiviral mechanism by IFN-stimulated genes
REACT_2099Cap-dependent Translation Initiation
REACT_75790Cytokine Signaling in Immune system
REACT_20639Deadenylation-dependent mRNA decay
REACT_20514Deadenylation of mRNA
REACT_2159Eukaryotic Translation Initiation
REACT_71Gene Expression
REACT_2085GTP hydrolysis and joining of the 60S ribosomal subunit
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_1195Insulin receptor signalling cascade
REACT_25229Interferon Signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_115831ISG15 antiviral mechanism
REACT_79L13a-mediated translational silencing of Ceruloplasmin expression
REACT_17015Metabolism of proteins
REACT_6964mTORC1-mediated signalling
REACT_6838mTOR signalling
REACT_976PI3K Cascade
REACT_456PKB-mediated events
REACT_125Processing of Capped Intron-Containing Pre-mRNA
REACT_6836Release of eIF4E
REACT_931Ribosomal scanning and start codon recognition
REACT_498Signaling by Insulin receptor
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_111102Signal Transduction
REACT_1014Translation
REACT_1979Translation initiation complex formation
REACT_1597Transport of Mature mRNA derived from an Intron-Containing Transcript
REACT_1835Transport of Mature mRNA Derived from an Intronless Transcript
REACT_338Transport of Mature mRNAs Derived from Intronless Transcripts
REACT_1281Transport of Mature Transcript to Cytoplasm
REACT_405Transport of the SLBP Dependant Mature mRNA
REACT_424Transport of the SLBP independent Mature mRNA
SMP Pathway Links
SMP IDDescription
SMP00682Leucine Stimulation on Insulin Signaling
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