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MGP000941

Record overview

MGPD IDMGP000941
Gene ID1978
SpeciesHomo sapiens (Human)
Gene Nameeukaryotic translation initiation factor 4E binding protein 1
Gene Symbol EIF4EBP1
SynonymsBP-1; 4EBP1; 4E-BP1; PHAS-I;
Alternate nameseukaryotic translation initiation factor 4E-binding protein 1; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1;
Chromosome8
Map Location8p12
SummaryThis gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for EIF4EBP1

Proteins

eukaryotic translation initiation factor 4E-binding protein 1
Refseq ID:NP_004086
Protein GI:4758258
UniProt ID:Q13541
mRNA ID:NM_004095
Length:118
RefSeq Status:
MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRN
SPEDKRAGGEESQFEMDI
 
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