MGP Database

MGP000941

Ontology/Pathway Information

Entrez Gene ID1978
Gene Nameeukaryotic translation initiation factor 4E binding protein 1
Gene Symbol EIF4EBP1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IDA:HPACnucleus
GO:0043234 IEA:EnsemblCprotein complex
GO:0030371 IDA:UniProtKBFtranslation repressor activity
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0000082 IMP:UniProtKBPG1/S transition of mitotic cell cycle
GO:0010467 TAS:ReactomePgene expression
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0030324 IEA:EnsemblPlung development
GO:0031333 IEA:EnsemblPnegative regulation of protein complex assembly
GO:0045947 IDA:UniProtKBPnegative regulation of translational initiation
GO:0045931 IMP:UniProtKBPpositive regulation of mitotic cell cycle
GO:0045471 IEA:EnsemblPresponse to ethanol
GO:0002931 IEA:EnsemblPresponse to ischemia
GO:0031929 IDA:UniProtKBPTOR signaling
GO:0006412 TAS:ReactomePtranslation
GO:0006413 TAS:ReactomePtranslational initiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1258Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
REACT_2099Cap-dependent Translation Initiation
REACT_2159Eukaryotic Translation Initiation
REACT_71Gene Expression
REACT_150210IGF1R signaling cascade
REACT_1195Insulin receptor signalling cascade
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_17015Metabolism of proteins
REACT_6964mTORC1-mediated signalling
REACT_6838mTOR signalling
REACT_976PI3K Cascade
REACT_456PKB-mediated events
REACT_6836Release of eIF4E
REACT_498Signaling by Insulin receptor
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_111102Signal Transduction
REACT_1014Translation
SMP Pathway Links
SMP IDDescription
SMP00682Leucine Stimulation on Insulin Signaling
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