MGP Database

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MGP000942

Ontology/Pathway Information

Entrez Gene ID1981
Gene Nameeukaryotic translation initiation factor 4 gamma, 1
Gene Symbol EIF4G1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0016281 TAS:ProtIncCeukaryotic translation initiation factor 4F complex
GO:0016020 IDA:UniProtKBCmembrane
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0008135 TAS:ProtIncFtranslation factor activity, nucleic acid binding
GO:0003743 TAS:UniProtKBFtranslation initiation factor activity
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0010467 TAS:ReactomePgene expression
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0000288 TAS:ReactomePnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000184 TAS:ReactomePnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000289 TAS:ReactomePnuclear-transcribed mRNA poly(A) tail shortening
GO:0006446 IMP:UniProtKBPregulation of translational initiation
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0006412 TAS:ReactomePtranslation
GO:0006413 TAS:ReactomePtranslational initiation
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1258Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
REACT_115676Antiviral mechanism by IFN-stimulated genes
REACT_25325AUF1 (hnRNP D0) destabilizes mRNA
REACT_2099Cap-dependent Translation Initiation
REACT_75790Cytokine Signaling in Immune system
REACT_20639Deadenylation-dependent mRNA decay
REACT_20514Deadenylation of mRNA
REACT_2159Eukaryotic Translation Initiation
REACT_71Gene Expression
REACT_2085GTP hydrolysis and joining of the 60S ribosomal subunit
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_1195Insulin receptor signalling cascade
REACT_25229Interferon Signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_115831ISG15 antiviral mechanism
REACT_79L13a-mediated translational silencing of Ceruloplasmin expression
REACT_17015Metabolism of proteins
REACT_6964mTORC1-mediated signalling
REACT_6838mTOR signalling
REACT_75886Nonsense-Mediated Decay (NMD)
REACT_75822Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
REACT_75768Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
REACT_976PI3K Cascade
REACT_456PKB-mediated events
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_931Ribosomal scanning and start codon recognition
REACT_6754S6K1-mediated signalling
REACT_6772S6K1 signalling
REACT_498Signaling by Insulin receptor
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_111102Signal Transduction
REACT_1014Translation
REACT_1979Translation initiation complex formation
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