MGP Database

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MGP000942

UniProt Annotations

Entry Information
Gene Nameeukaryotic translation initiation factor 4 gamma, 1
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing, Alternative initiation; Named isoforms=8; Name=A; IsoId=Q04637-1; Sequence=Displayed; Name=B; IsoId=Q04637-3; Sequence=VSP_018720; Note=Produced by alternative initiation at Met-41 of isoform A.; Name=C; IsoId=Q04637-4; Sequence=VSP_018721; Note=Produced by alternative initiation at Met-88 of isoform A.; Name=D; IsoId=Q04637-5; Sequence=VSP_018722; Note=Produced by alternative initiation at Met-165 of isoform A.; Name=E; IsoId=Q04637-6; Sequence=VSP_018723; Note=Produced by alternative initiation at Met-197 of isoform A.; Name=7; IsoId=Q04637-7; Sequence=VSP_018723, VSP_047397; Note=Produced by alternative splicing.; Name=8; IsoId=Q04637-8; Sequence=VSP_047397; Note=Produced by alternative splicing.; Name=9; IsoId=Q04637-9; Sequence=VSP_047396; Note=Produced by alternative splicing. Gene prediction based on EST data.;
DiseaseParkinson disease 18 (PARK18) [MIM:614251]: An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269|PubMed:21907011}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionComponent of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
InteractionO00571:DDX3X; NbExp=3; IntAct=EBI-73711, EBI-353779; O75822:EIF3J; NbExp=2; IntAct=EBI-73711, EBI-366647; P60842:EIF4A1; NbExp=7; IntAct=EBI-73711, EBI-73449; P06730:EIF4E; NbExp=2; IntAct=EBI-73711, EBI-73440; Q14103-4:HNRNPD; NbExp=3; IntAct=EBI-73711, EBI-432545; P11940:PABPC1; NbExp=2; IntAct=EBI-73711, EBI-81531;
PtmFollowing infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription. {ECO:0000269|PubMed:11034318, ECO:0000269|PubMed:8396129, ECO:0000269|PubMed:9755863}.
PtmPhosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1. {ECO:0000269|PubMed:16964243, ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:21576361}.
Sequence CautionSequence=AAC78444.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC82471.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA02185.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAD18554.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
SimilarityBelongs to the eukaryotic initiation factor 4G family. {ECO:0000305}.
SimilarityContains 1 MI domain. {ECO:0000255|PROSITE- ProRule:PRU00698}.
SimilarityContains 1 MIF4G domain. {ECO:0000305}.
SimilarityContains 1 W2 domain. {ECO:0000255|PROSITE- ProRule:PRU00695}.
SubuniteIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. Interacts with RBM4. Interacts with HNRNPD/AUF1; the interaction requires RNA. {ECO:0000269|PubMed:10970864, ECO:0000269|PubMed:10996799, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:12086624, ECO:0000269|PubMed:16513844, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:18025107, ECO:0000269|PubMed:18799579, ECO:0000269|PubMed:24423872, ECO:0000269|PubMed:7651417, ECO:0000269|PubMed:7935836, ECO:0000269|PubMed:8521827, ECO:0000269|PubMed:9372926, ECO:0000269|PubMed:9755181, ECO:0000269|PubMed:9857202, ECO:0000269|PubMed:9878069}.
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