MGP Database

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MGP000947

Record overview

MGPD IDMGP000947
Gene ID1994
SpeciesHomo sapiens (Human)
Gene NameELAV like RNA binding protein 1
Gene Symbol ELAVL1
SynonymsHUR; Hua; MelG; ELAV1;
Alternate namesELAV-like protein 1; Hu antigen R; hu-antigen R; embryonic lethal, abnormal vision, drosophila, homolog-like 1; ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R);
Chromosome19
Map Location19p13.2
SummaryThe protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
OrthologsView orthologs and multiple alignments for ELAVL1

Proteins

ELAV-like protein 1
Refseq ID:NP_001410
Protein GI:38201714
UniProt ID:Q15717
mRNA ID:NM_001419
Length:326
RefSeq Status:
MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSS
EVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLY
HSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAM
AIASLNGYRLGDKILQVSFKTNKSHK
 
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