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MGP000947

UniProt Annotations

Entry Information
Gene NameELAV like RNA binding protein 1
Protein EntryELAV1_HUMAN
UniProt IDQ15717
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15717-1; Sequence=Displayed; Name=2; IsoId=Q15717-2; Sequence=VSP_056148; Note=No experimental confirmation available.;
FunctionRNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. {ECO:0000269|PubMed:19029303}.
InteractionP0CG48:UBC; NbExp=4; IntAct=EBI-374260, EBI-3390054;
PtmMethylated at Arg-217 by CARM1 in macrophages in response to LPS challenge. {ECO:0000269|PubMed:12237300}.
PtmPhosphorylated by MAPKAPK2. {ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692}.
SimilarityBelongs to the RRM elav family. {ECO:0000305}.
SimilarityContains 3 RRM (RNA recognition motif) domains. {ECO:0000255|PROSITE-ProRule:PRU00176}.
Subcellular LocationCytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2.
SubunitInteracts with ANP32A (By similarity). Interact with ZNF385A; the interaction is indirect and mRNA-dependent and may regulate p53/TP53 expression (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with ANP32A, AGO1 and AGO2. Interacts with IGF2BP2 and IGF2BP3. {ECO:0000250, ECO:0000269|PubMed:11729309, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23640942}.
Tissue SpecificityUbiquitous.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ELAVL1ID44237ch19p13.html";
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