MGP Database

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MGP000948

UniProt Annotations

Entry Information
Gene NameELK1, member of ETS oncogene family
Protein EntryELK1_HUMAN
UniProt IDP19419
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P19419-1; Sequence=Displayed; Name=2; Synonyms=ELKV; IsoId=P19419-2; Sequence=VSP_001466, VSP_001467;
FunctionStimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.
InteractionP27361:MAPK3; NbExp=2; IntAct=EBI-726632, EBI-73995; P63165:SUMO1; NbExp=5; IntAct=EBI-726632, EBI-80140; P63279:UBE2I; NbExp=7; IntAct=EBI-726632, EBI-80168;
PtmOn mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. {ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:7889942, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:9430721}.
PtmSumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
SimilarityBelongs to the ETS family. {ECO:0000305}.
SimilarityContains 1 ETS DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00237}.
Subcellular LocationNucleus.
SubunitInteracts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9. {ECO:0000269|PubMed:15920481, ECO:0000269|PubMed:17296730}.
Tissue SpecificityLung and testis.
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