MGP Database

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MGP000992

Record overview

MGPD IDMGP000992
Gene ID2104
SpeciesHomo sapiens (Human)
Gene Nameestrogen-related receptor gamma
Gene Symbol ESRRG
SynonymsERR3; NR3B3; ERRgamma;
Alternate namesestrogen-related receptor gamma; ERR gamma-2; estrogen receptor-related protein 3; nuclear receptor subfamily 3 group B member 3;
Chromosome1
Map Location1q41
SummaryThis gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for ESRRG

Proteins

estrogen-related receptor gamma isoform 1
Refseq ID:NP_001429
Protein GI:45545433
UniProt ID:P62508
mRNA ID:NM_001438
Length:458
RefSeq Status:
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKL
YDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRL
DRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL
LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQ
DYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_001127757
Protein GI:197209821
UniProt ID:P62508
mRNA ID:NM_001134285
Length:435
RefSeq Status:
MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSM
PKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLN
PQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDE
LVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPL
LRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_001230439
Protein GI:343780854
UniProt ID:P62508
mRNA ID:NM_001243510
Length:435
RefSeq Status:
Protein sequence is identical to GI:197209821 (mRNA isoform)
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_001230438
Protein GI:343780852
UniProt ID:P62508
mRNA ID:NM_001243509
Length:435
RefSeq Status:
Protein sequence is identical to GI:197209821 (mRNA isoform)
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_001230448
Protein GI:343780868
UniProt ID:P62508
mRNA ID:NM_001243519
Length:435
RefSeq Status:
Protein sequence is identical to GI:197209821 (mRNA isoform)
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_001230444
Protein GI:343780864
UniProt ID:P62508
mRNA ID:NM_001243515
Length:435
RefSeq Status:
Protein sequence is identical to GI:197209821 (mRNA isoform)
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_996318
Protein GI:45545429
UniProt ID:P62508
mRNA ID:NM_206595
Length:435
RefSeq Status:
Protein sequence is identical to GI:197209821 (mRNA isoform)
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_001230443
Protein GI:343780862
UniProt ID:P62508
mRNA ID:NM_001243514
Length:435
RefSeq Status:
Protein sequence is identical to GI:197209821 (mRNA isoform)
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_001230442
Protein GI:343780860
UniProt ID:P62508
mRNA ID:NM_001243513
Length:435
RefSeq Status:
Protein sequence is identical to GI:197209821 (mRNA isoform)
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_001230441
Protein GI:343780858
UniProt ID:P62508
mRNA ID:NM_001243512
Length:435
RefSeq Status:
Protein sequence is identical to GI:197209821 (mRNA isoform)
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_001230440
Protein GI:343780856
UniProt ID:P62508
mRNA ID:NM_001243511
Length:435
RefSeq Status:
Protein sequence is identical to GI:197209821 (mRNA isoform)
 
estrogen-related receptor gamma isoform 2
Refseq ID:NP_996317
Protein GI:45545427
UniProt ID:P62508
mRNA ID:NM_206594
Length:435
RefSeq Status:
Protein sequence is identical to GI:197209821 (mRNA isoform)
 
estrogen-related receptor gamma isoform 3
Refseq ID:NP_001230434
Protein GI:343776782
UniProt ID:P62508
mRNA ID:NM_001243505
Length:207
RefSeq Status:
MPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQ
LVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFL
EMLEAKV
 
estrogen-related receptor gamma isoform 4
Refseq ID:NP_001230435
Protein GI:343780848
UniProt ID:P62508
mRNA ID:NM_001243506
Length:273
RefSeq Status:
MKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKH
IPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDV
EAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
 
estrogen-related receptor gamma isoform 5
Refseq ID:NP_001230436
Protein GI:343780850
UniProt ID:P62508
mRNA ID:NM_001243507
Length:396
RefSeq Status:
MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSM
PKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDI
KALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLE
KEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
 
estrogen-related receptor gamma isoform 6
Refseq ID:NP_001230447
Protein GI:343780866
UniProt ID:P62508
mRNA ID:NM_001243518
Length:470
RefSeq Status:
MWRECDWGLGAVKSDLACVPSAKRLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSG
PVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLK
EGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPLLWSDPADNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPG
FSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAV
QKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
 
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