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MGP000992

UniProt Annotations

Entry Information
Gene Nameestrogen-related receptor gamma
Protein EntryERR3_HUMAN
UniProt IDP62508
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Long; IsoId=P62508-1, O75454-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P62508-2, O75454-2; Sequence=VSP_003702; Name=3; IsoId=P62508-3; Sequence=VSP_003702, VSP_013301; Name=4; IsoId=P62508-4; Sequence=VSP_003702, VSP_045980; Note=No experimental confirmation available.; Name=5; IsoId=P62508-5; Sequence=VSP_047156, VSP_013301; Note=Gene prediction based on EST data.;
Developmental StageExpressed at high levels in fetal brain and also in the fetal kidney, lung and liver. {ECO:0000269|PubMed:9676434}.
FunctionOrphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle. {ECO:0000250, ECO:0000269|PubMed:11864604, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653, ECO:0000269|PubMed:23836911}.
InteractionQ9UBK2:PPARGC1A; NbExp=3; IntAct=EBI-2834260, EBI-765486;
MiscellaneousNo physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.
PtmAcetylated by PCAF/KAT2 (in vitro). {ECO:0000269|PubMed:20484414}.
PtmPhosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity. {ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653}.
PtmSumoylation on Lys-40 is enhanced by phosphorylation at Ser- 45 and represses transcriptional activity. {ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653}.
Sequence CautionSequence=AAH08218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA74855.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the nuclear hormone receptor family. NR3 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitHomodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2. {ECO:0000250, ECO:0000269|PubMed:14651967, ECO:0000269|PubMed:16307879, ECO:0000269|PubMed:16990259}.
Tissue SpecificityExpressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland. {ECO:0000269|PubMed:14651967, ECO:0000269|PubMed:9676434}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ESRRGID45840ch1q41.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/esrrg/";
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