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MGP001006

Record overview

MGPD IDMGP001006
Gene ID2150
SpeciesHomo sapiens (Human)
Gene Namecoagulation factor II (thrombin) receptor-like 1
Gene Symbol F2RL1
SynonymsPAR2; GPR11;
Alternate namesproteinase-activated receptor 2; G-protein coupled receptor 11; coagulation factor II receptor-like 1; protease-activated receptor 2; thrombin receptor-like 1;
Chromosome5
Map Location5q13
SummaryCoagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for F2RL1

Proteins

proteinase-activated receptor 2 precursor
Refseq ID:NP_005233
Protein GI:34577052
UniProt ID:P55085
mRNA ID:NM_005242
Length:397
RefSeq Status:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVF
LFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWL
LILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICF
TPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
 
sig_peptide: 1..25
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P55085.1)
calculated_mol_wt: 2448
peptide sequence: 
MRSPSAAWLLGAAILLAASLSCSGT

mat_peptide: 37..397
product: Proteinase-activated receptor 2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55085.1)
calculated_mol_wt: 40511
peptide sequence: 
SLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHI
HGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLV
GDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLN
SCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
 
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