MGP Database

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MGP001026

Ontology/Pathway Information

Entrez Gene ID2180
Gene Nameacyl-CoA synthetase long-chain family member 1
Gene Symbol ACSL1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0016020 IDA:UniProtKBCmembrane
GO:0005741 TAS:ReactomeCmitochondrial outer membrane
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0005778 IEA:UniProtKB-SubCellCperoxisomal membrane
GO:0005886 IEA:EnsemblCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004467 IDA:UniProtKBFlong-chain fatty acid-CoA ligase activity
GO:0033211 IEA:EnsemblPadiponectin-activated signaling pathway
GO:0036109 TAS:ReactomePalpha-linolenic acid metabolic process
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0043651 TAS:ReactomePlinoleic acid metabolic process
GO:0008610 IDA:UniProtKBPlipid biosynthetic process
GO:0044539 IDA:UniProtKBPlong-chain fatty acid import
GO:0001676 IDA:UniProtKBPlong-chain fatty acid metabolic process
GO:0035338 TAS:ReactomePlong-chain fatty-acyl-CoA biosynthetic process
GO:0071902 IEA:EnsemblPpositive regulation of protein serine/threonine kinase activity
GO:0042493 IEA:EnsemblPresponse to drug
GO:0007584 IEA:EnsemblPresponse to nutrient
GO:0034201 IEA:EnsemblPresponse to oleic acid
GO:0014070 IEA:EnsemblPresponse to organic cyclic compound
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0019432 TAS:ReactomePtriglyceride biosynthetic process
GO:0033559 TAS:ReactomePunsaturated fatty acid metabolic process
GO:0042178 IEA:EnsemblPxenobiotic catabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_121147alpha-linolenic acid (ALA) metabolism
REACT_121284alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_1319Fatty Acyl-CoA Biosynthesis
REACT_121100Linoleic acid (LA) metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_380Synthesis of very long-chain fatty acyl-CoAs
REACT_1190Triglyceride Biosynthesis
SMP Pathway Links
SMP IDDescription
SMP00516Adrenoleukodystrophy, X-linked
SMP00052Beta Oxidation of Very Long Chain Fatty Acids
SMP00517Carnitine-acylcarnitine translocase deficiency
SMP00538Carnitine palmitoyl transferase deficiency (I)
SMP00541Carnitine palmitoyl transferase deficiency (II)
SMP00181Ethylmalonic Encephalopathy
SMP00051Fatty acid Metabolism
SMP00185Glutaric Aciduria Type I
SMP00539Long chain acyl-CoA dehydrogenase deficiency (LCAD)
SMP00542Medium chain acyl-coa dehydrogenase deficiency (MCAD)
SMP00482Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
SMP00030Oxidation of Branched Chain Fatty Acids
SMP00235Short Chain Acyl CoA Dehydrogenase Deficiency (SCAD Deficiency)
SMP00545Trifunctional protein deficiency
SMP00540Very-long-chain acyl coa dehydrogenase deficiency (VLCAD)
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