MGP Database

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MGP001026

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase long-chain family member 1
Protein EntryACSL1_HUMAN
UniProt IDP33121
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P33121-1; Sequence=Displayed; Name=2; IsoId=P33121-2; Sequence=VSP_009604; Note=May be due to a competing acceptor splice site. No experimental confirmation available.; Name=3; IsoId=P33121-3; Sequence=VSP_054391; Note=No experimental confirmation available.;
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Developmental StageExpressed during the early stages of erythroid development while expression is very low in reticulocytes and young erythrocytes.
FunctionActivation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
Sequence CautionSequence=BAC04704.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationMitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Tissue SpecificityHighly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. {ECO:0000269|PubMed:10548543}.
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