MGP Database

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MGP001036

Ontology/Pathway Information

Entrez Gene ID2194
Gene Namefatty acid synthase
Gene Symbol FASN
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0042587 IEA:EnsemblCglycogen granule
GO:0005794 IDA:HPACGolgi apparatus
GO:0042470 IEA:UniProtKB-SubCellCmelanosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005886 IDA:HPACplasma membrane
GO:0047451 IEA:UniProtKB-ECF3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO:0004317 IEA:InterProF3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO:0004316 IEA:UniProtKB-ECF3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0004315 IEA:UniProtKB-ECF3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0004313 IEA:UniProtKB-ECF[acyl-carrier-protein] S-acetyltransferase activity
GO:0004314 IEA:UniProtKB-ECF[acyl-carrier-protein] S-malonyltransferase activity
GO:0008144 IEA:EnsemblFdrug binding
GO:0047117 IEA:UniProtKB-ECFenoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
GO:0004319 IEA:InterProFenoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
GO:0004312 TAS:ReactomeFfatty acid synthase activity
GO:0016295 IEA:UniProtKB-ECFmyristoyl-[acyl-carrier-protein] hydrolase activity
GO:0070402 IEA:EnsemblFNADPH binding
GO:0004320 IEA:UniProtKB-ECFoleoyl-[acyl-carrier-protein] hydrolase activity
GO:0016296 IEA:UniProtKB-ECFpalmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0008270 IEA:InterProFzinc ion binding
GO:0006084 IEA:EnsemblPacetyl-CoA metabolic process
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0071353 IEA:EnsemblPcellular response to interleukin-4
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0006633 IEA:UniProtKB-KWPfatty acid biosynthetic process
GO:0006631 TAS:ProtIncPfatty acid metabolic process
GO:0035338 TAS:ReactomePlong-chain fatty-acyl-CoA biosynthetic process
GO:0001649 IDA:UniProtKBPosteoblast differentiation
GO:0015939 TAS:ReactomePpantothenate metabolic process
GO:0031325 TAS:ReactomePpositive regulation of cellular metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0019432 TAS:ReactomePtriglyceride biosynthetic process
GO:0006766 TAS:ReactomePvitamin metabolic process
GO:0006767 TAS:ReactomePwater-soluble vitamin metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147904Activation of gene expression by SREBF (SREBP)
REACT_2122ChREBP activates metabolic gene expression
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_1319Fatty Acyl-CoA Biosynthesis
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_147797Regulation of cholesterol biosynthesis by SREBP (SREBF)
REACT_1190Triglyceride Biosynthesis
REACT_11172Vitamin B5 (pantothenate) metabolism
SMP Pathway Links
SMP IDDescription
SMP00456Fatty Acid Biosynthesis
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