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MGP001036

UniProt Annotations

Entry Information
Gene Namefatty acid synthase
Protein EntryFAS_HUMAN
UniProt IDP49327
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH. {ECO:0000269|PubMed:7567999}.
Catalytic ActivityA (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O. {ECO:0000269|PubMed:7567999}.
Catalytic ActivityAcetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]. {ECO:0000269|PubMed:7567999}.
Catalytic ActivityAcetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+). {ECO:0000269|PubMed:7567999}.
Catalytic ActivityAcyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. {ECO:0000269|PubMed:7567999}.
Catalytic ActivityAn acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH. {ECO:0000269|PubMed:7567999}.
Catalytic ActivityMalonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]. {ECO:0000269|PubMed:7567999}.
Catalytic ActivityOleoyl-[acyl-carrier-protein] + H(2)O = [acyl- carrier-protein] + oleate. {ECO:0000269|PubMed:7567999}.
FunctionFatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
InteractionQ99IB8:- (xeno); NbExp=6; IntAct=EBI-356658, EBI-6927928;
MiscellaneousThe relatively low beta-ketoacyl synthase activity may be attributable to the low 4'-phosphopantetheine content of the protein.
Sequence CautionSequence=AAB35516.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC50259.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=BAE06070.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 acyl carrier domain. {ECO:0000255|PROSITE- ProRule:PRU00258}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitHomodimer which is arranged in a head to tail fashion. {ECO:0000269|PubMed:17618296, ECO:0000269|PubMed:18022563, ECO:0000269|Ref.23}.
Tissue SpecificityUbiquitous. Prominent expression in brain, lung, and liver. {ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:7595075}.
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