MGP Database

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MGP001048

UniProt Annotations

Entry Information
Gene NameFc fragment of IgG, low affinity IIa, receptor (CD32)
Protein EntryFCG2A_HUMAN
UniProt IDP12318
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P12318-1; Sequence=Displayed; Name=2; IsoId=P12318-2; Sequence=VSP_036865;
FunctionBinds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. {ECO:0000269|PubMed:19011614}.
PtmPhosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK. {ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:8756631}.
Sequence CautionSequence=AAA35932.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:19011614}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011614}.
SubunitInteracts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK. {ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:19011614, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:8327512}.
Tissue SpecificityFound on monocytes, neutrophils and eosinophil platelets.
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