MGP Database

MGP001049

Record overview

MGPD ID	MGP001049
Gene ID	2213
Species	Homo sapiens (Human)
Gene Name	Fc fragment of IgG, low affinity IIb, receptor (CD32)
Gene Symbol	FCGR2B
Synonyms	CD32; FCG2; CD32B; FCGR2; IGFR2;
Alternate names	low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma RIIb; fc-gamma RII-b; fc-gamma-RIIb; fcRII-b; igG Fc receptor II-b;
Chromosome	1
Map Location	1q23
Summary	The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Orthologs	View orthologs and multiple alignments for FCGR2B

Proteins

low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

Refseq ID:	NP_003992
Protein GI:	50511930
UniProt ID:	P31994
mRNA ID:	NM_004001
Length:	310
RefSeq Status:

`MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYR FKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNI GYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDA LEEPDDQNRI`

sig_peptide: 1..42
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4570
peptide sequence: 
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAG

sig_peptide: 1..45
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4840
peptide sequence: 
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPA

low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor

Refseq ID:	NP_001002273
Protein GI:	50511932
UniProt ID:	P31994
mRNA ID:	NM_001002273
Length:	290
RefSeq Status:

`MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRF KANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIG YTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISANPTNPDEADKVGAENTITYSLLMHPDALEEPDDQNRI`

low affinity immunoglobulin gamma Fc region receptor II-b isoform 3 precursor
`sig_peptide: 1..42 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 4570 peptide sequence: MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAG`

Refseq ID:	NP_001002274
Protein GI:	50511926
UniProt ID:	P31994
mRNA ID:	NM_001002274
Length:	291
RefSeq Status:

`MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYR FKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNI GYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISANPTNPDEADKVGAENTITYSLLMHPDALEEPDDQNRI`

sig_peptide: 1..42
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4570
peptide sequence: 
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAG

sig_peptide: 1..45
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4840
peptide sequence: 
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPA

sig_peptide: 1..42
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4570
peptide sequence: 
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAG

sig_peptide: 1..45
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4840
peptide sequence: 
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPA

low affinity immunoglobulin gamma Fc region receptor II-b isoform 4 precursor

Refseq ID:	NP_001002275
Protein GI:	50511928
UniProt ID:	P31994
mRNA ID:	NM_001002275
Length:	309
RefSeq Status:

`MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRF KANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIG YTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDAL EEPDDQNRI`

sig_peptide: 1..42
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4570
peptide sequence: 
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAG

sig_peptide: 1..45
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4840
peptide sequence: 
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPA

sig_peptide: 1..42
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4570
peptide sequence: 
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAG

low affinity immunoglobulin gamma Fc region receptor II-b isoform 5

Refseq ID:	NP_001177757
Protein GI:	299890847
UniProt ID:	P31994
mRNA ID:	NM_001190828
Length:	303
RefSeq Status:

`MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNND SGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSS KPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDALEEPDDQ NRI`

`sig_peptide: 1..42 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 4570 peptide sequence: MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAG`