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MGP001049

UniProt Annotations

Entry Information
Gene NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Protein EntryFCG2B_HUMAN
UniProt IDP31994
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=IIB1; IsoId=P31994-1; Sequence=Displayed; Name=IIB2; IsoId=P31994-2; Sequence=VSP_002643; Name=IIB3; IsoId=P31994-3; Sequence=VSP_002642;
CautionHas sometimes been attributed to correspond to FcR-IIC. {ECO:0000305}.
DiseaseNote=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.
DiseaseSystemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:12115230, ECO:0000269|PubMed:20385827}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.
FunctionReceptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
InteractionP01857:IGHG1; NbExp=31; IntAct=EBI-724784, EBI-356114; Q92835:INPP5D; NbExp=2; IntAct=EBI-724784, EBI-1380477; P16333:NCK1; NbExp=2; IntAct=EBI-724784, EBI-389883; P19174:PLCG1; NbExp=2; IntAct=EBI-724784, EBI-79387; P29350:PTPN6; NbExp=3; IntAct=EBI-724784, EBI-78260;
PolymorphismNote=FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162].
PtmPhosphorylated by the SRC-type Tyr-kinases LYN and BLK. {ECO:0000269|PubMed:8756631}.
Sequence CautionSequence=CAA35645.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationCell membrane; Single-pass type I membrane protein.
SubunitIsoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. {ECO:0000269|PubMed:15914856, ECO:0000269|PubMed:8327512, ECO:0000269|PubMed:9232445}.
Tissue SpecificityIs the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FCGR2BID397.html";
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