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MGP001051

Record overview

MGPD IDMGP001051
Gene ID2219
SpeciesHomo sapiens (Human)
Gene Nameficolin (collagen/fibrinogen domain containing) 1
Gene Symbol FCN1
SynonymsFCNM;
Alternate namesficolin-1; M-ficolin; collagen/fibrinogen domain-containing protein 1; ficolin (collagen/fibrinogen domain-containing) 1; ficolin-A; ficolin-alpha;
Chromosome9
Map Location9q34
Summary The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for FCN1

Proteins

ficolin-1 precursor
Refseq ID:NP_001994
Protein GI:8051584
UniProt ID:O00602
mRNA ID:NM_002003
Length:326
RefSeq Status:
MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRG
EKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQG
SSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY
ANGINWSAAKGYKYSYKVSEMKVRPA
 
sig_peptide: 1..27
calculated_mol_wt: 2880
peptide sequence: 
MELSGATMARGLAVLLVLFLHIKNLPA

mat_peptide: 28..326
product: ficolin-1
calculated_mol_wt: 32217
peptide sequence: 
QAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYF
LSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVAD
EAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA
 
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