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MGP001054

Record overview

MGPD IDMGP001054
Gene ID2224
SpeciesHomo sapiens (Human)
Gene Namefarnesyl diphosphate synthase
Gene Symbol FDPS
SynonymsFPS; FPPS;
Alternate namesfarnesyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; FPP synthase; FPP synthetase; dimethylallyltranstransferase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; geranyltranstransferase;
Chromosome1
Map Location1q22
EC Number2.5.1.10
SummaryThis gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
OrthologsView orthologs and multiple alignments for FDPS

Proteins

farnesyl pyrophosphate synthase isoform a
Refseq ID:NP_001129293
Protein GI:209571582
UniProt ID:P14324
mRNA ID:NM_001135821
Length:419
RefSeq Status:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMG
HPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANL
LEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAA
PLPPAVFLGLARKIYKRRK
 
farnesyl pyrophosphate synthase isoform a
Refseq ID:NP_001995
Protein GI:4503685
UniProt ID:P14324
mRNA ID:NM_002004
Length:419
RefSeq Status:
Protein sequence is identical to GI:209571582 (mRNA isoform)
 
farnesyl pyrophosphate synthase isoform b
Refseq ID:NP_001129294
Protein GI:209571584
UniProt ID:P14324
mRNA ID:NM_001135822
Length:353
RefSeq Status:
MNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFL
VADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYK
TAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVAR
VKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
 
farnesyl pyrophosphate synthase isoform b
Refseq ID:NP_001229753
Protein GI:338797808
UniProt ID:P14324
mRNA ID:NM_001242824
Length:353
RefSeq Status:
Protein sequence is identical to GI:209571584 (mRNA isoform)
 
farnesyl pyrophosphate synthase isoform c
Refseq ID:NP_001229754
Protein GI:338797810
UniProt ID:P14324
mRNA ID:NM_001242825
Length:248
RefSeq Status:
MDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYS
FYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALY
EELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
 
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