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MGP001054

UniProt Annotations

Entry Information
Gene Namefarnesyl diphosphate synthase
Protein EntryFPPS_HUMAN
UniProt IDP14324
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14324-1; Sequence=Displayed; Name=2; IsoId=P14324-2; Sequence=VSP_046958;
Catalytic ActivityDimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. {ECO:0000269|PubMed:16684881}.
Catalytic ActivityGeranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate. {ECO:0000269|PubMed:16684881}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 3 Mg(2+) ions per subunit.;
Enzyme RegulationInactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell. {ECO:0000269|PubMed:18005724}.
FunctionKey enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
PathwayIsoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
PathwayIsoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Sequence CautionSequence=BAA03523.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. Interacts with RSAD2. Interacts with HTLV-1 protein p13(II). {ECO:0000269|PubMed:11773414, ECO:0000269|PubMed:16892359, ECO:0000269|PubMed:18005724}.
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