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MGP001079

Record overview

MGPD IDMGP001079
Gene ID2268
SpeciesHomo sapiens (Human)
Gene NameFGR proto-oncogene, Src family tyrosine kinase
Gene Symbol FGR
SynonymsSRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr;
Alternate namestyrosine-protein kinase Fgr; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; c-fgr protooncogene; c-src-2 proto-oncogene; feline Gardner-Rasheed sarcoma viral oncogene homolog; p55-c-fgr protein; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog;
Chromosome1
Map Location1p36.2-p36.1
EC Number2.7.10.2
SummaryThis gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for FGR

Proteins

tyrosine-protein kinase Fgr
Refseq ID:NP_001036194
Protein GI:112382241
UniProt ID:P09769
mRNA ID:NM_001042729
Length:529
RefSeq Status:
MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTK
GEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI
RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD
FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPE
ERPTFEYLQSFLEDYFTSAEPQYQPGDQT
 
tyrosine-protein kinase Fgr
Refseq ID:NP_005239
Protein GI:4885235
UniProt ID:P09769
mRNA ID:NM_005248
Length:529
RefSeq Status:
Protein sequence is identical to GI:112382241 (mRNA isoform)
 
tyrosine-protein kinase Fgr
Refseq ID:NP_001036212
Protein GI:112382244
UniProt ID:P09769
mRNA ID:NM_001042747
Length:529
RefSeq Status:
Protein sequence is identical to GI:112382241 (mRNA isoform)
 
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