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MGP001081

UniProt Annotations

Entry Information

Gene Name	four and a half LIM domains 2
Protein Entry	FHL2_HUMAN
UniProt ID	Q14192
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14192-1; Sequence=Displayed; Name=2; IsoId=Q14192-2; Sequence=VSP_056999, VSP_057000;
Domain	The third LIM zinc-binding mediates interaction with E4F1.
Function	May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. {ECO:0000269\|PubMed:15692560, ECO:0000269\|PubMed:16652157, ECO:0000269\|PubMed:18853468}.
Interaction	Self; NbExp=3; IntAct=EBI-701903, EBI-701903; P18847:ATF3; NbExp=3; IntAct=EBI-701903, EBI-712767; P38398:BRCA1; NbExp=6; IntAct=EBI-701903, EBI-349905; Q12778:FOXO1; NbExp=8; IntAct=EBI-701903, EBI-1108782; Q96EB6:SIRT1; NbExp=2; IntAct=EBI-701903, EBI-1802965; Q9NYA1:SPHK1; NbExp=7; IntAct=EBI-701903, EBI-985303; Q9H9D4:ZNF408; NbExp=3; IntAct=EBI-701903, EBI-347633;
Similarity	Contains 4 LIM zinc-binding domains. {ECO:0000255\|PROSITE-ProRule:PRU00125}.
Subcellular Location	Cytoplasm. Nucleus.
Subunit	Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7. Interacts with SIRT1 and FOXO1. {ECO:0000269\|PubMed:11813260, ECO:0000269\|PubMed:12432079, ECO:0000269\|PubMed:15692560, ECO:0000269\|PubMed:16652157, ECO:0000269\|PubMed:18853468}.
Tissue Specificity	Expressed in skeletal muscle and heart. {ECO:0000269\|PubMed:11813260}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FHL2ID44092ch2q12.html";