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MGP001084

UniProt Annotations

Entry Information
Gene NameFK506 binding protein 1B, 12.6 kDa
Protein EntryFKB1B_HUMAN
UniProt IDP68106
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P68106-1, Q16645-1; Sequence=Displayed; Name=2; IsoId=P68106-2, Q16645-2; Sequence=VSP_005184;
Catalytic ActivityPeptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme RegulationInhibited by both FK506 and rapamycin.
FunctionHas the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
InteractionQ92736:RYR2; NbExp=2; IntAct=EBI-6693977, EBI-1170425;
SimilarityBelongs to the FKBP-type PPIase family. FKBP1 subfamily. {ECO:0000305}.
SimilarityContains 1 PPIase FKBP-type domain. {ECO:0000255|PROSITE-ProRule:PRU00277}.
Subcellular LocationCytoplasm {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}.
SubunitIdentified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2. {ECO:0000269|PubMed:10830164}.
Tissue SpecificityDetected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. {ECO:0000269|PubMed:10830164}.
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