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MGP001086

UniProt Annotations

Entry Information
Gene Nameforkhead box M1
Protein EntryFOXM1_HUMAN
UniProt IDQ08050
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Comment=Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human.; Name=1; Synonyms=FoxM1C, FOXM1-c; IsoId=Q08050-1; Sequence=Displayed; Name=2; Synonyms=FoxM1B, FOXM1-b; IsoId=Q08050-2; Sequence=VSP_001547; Name=4; Synonyms=FoxM1A, FOXM1-a; IsoId=Q08050-3; Sequence=VSP_001548;
Developmental StageEmbryonic expression pattern: liver, lung, intestine, kidney, urinary tract; adult expression pattern: intestine, colon, testis and thymus.
DomainWithin the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.
FunctionTranscriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045}.
InductionInduced during liver regeneration and oxidative stress.
InteractionP24864:CCNE1; NbExp=2; IntAct=EBI-866480, EBI-519526; Q00534:CDK6; NbExp=2; IntAct=EBI-866499, EBI-295663; P35222:CTNNB1; NbExp=16; IntAct=EBI-866480, EBI-491549; P03129:E7 (xeno); NbExp=3; IntAct=EBI-866499, EBI-866453; O43524:FOXO3; NbExp=2; IntAct=EBI-866480, EBI-1644164;
PtmPhosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20068231}.
SimilarityContains 1 fork-head DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00089}.
Subcellular LocationNucleus.
Tissue SpecificityExpressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FOXM1ID40631ch12p13.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/foxm1/";
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