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MGP001095

UniProt Annotations

Entry Information
Gene Nameflavin containing monooxygenase 3
Protein EntryFMO3_HUMAN
UniProt IDP31513
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=21 uM for trimethylamine (at pH 8.5) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=31 uM for trimethylamine (at pH 7.4 and 37 degrees Celsius) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=43 uM for benzydamine (at pH 7.4 and 37 degrees Celsius) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=55.7 uM for ethylenethiourea (at pH 8.5) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=71.8 uM for methimazole (at pH 8.5) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=150.1 uM for sulindac (at pH 8.5) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949}; KM=248 uM for methyl p-tolyl sulfide (at pH 7.4 and 37 degrees Celsius) {ECO:0000269|PubMed:17050781, ECO:0000269|PubMed:17531949};
Catalytic ActivityN,N-dimethylaniline + NADPH + O(2) = N,N- dimethylaniline N-oxide + NADP(+) + H(2)O. {ECO:0000269|PubMed:9536088}.
Catalytic ActivityN,N,N-trimethylamine + NADPH + O(2) = N,N,N- trimethylamine N-oxide + NADP(+) + H(2)O. {ECO:0000269|PubMed:9536088}.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
DiseaseTrimethylaminuria (TMAU) [MIM:602079]: Inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Affected individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine. {ECO:0000269|PubMed:10338091, ECO:0000269|PubMed:10479479, ECO:0000269|PubMed:11191884, ECO:0000269|PubMed:12893987, ECO:0000269|PubMed:9536088}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionInvolved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds.
SimilarityBelongs to the FMO family. {ECO:0000305}.
Subcellular LocationMicrosome membrane. Endoplasmic reticulum membrane.
Tissue SpecificityLiver.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fmo3/";
Web ResourceName=Protein Spotlight; Note=A case for discomfort - Issue 149 of June 2013; URL="http://web.expasy.org/spotlight/back_issues/149";
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