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MGP001155

Record overview

MGPD IDMGP001155
Gene ID2597
SpeciesHomo sapiens (Human)
Gene Nameglyceraldehyde-3-phosphate dehydrogenase
Gene Symbol GAPDH
SynonymsG3PD; GAPD; HEL-S-162eP;
Alternate namesglyceraldehyde-3-phosphate dehydrogenase; aging-associated gene 9 protein; epididymis secretory sperm binding protein Li 162eP; peptidyl-cysteine S-nitrosylase GAPDH;
Chromosome12
Map Location12p13
EC Number1.2.1.12
SummaryThis gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
OrthologsView orthologs and multiple alignments for GAPDH

Proteins

glyceraldehyde-3-phosphate dehydrogenase isoform 1
Refseq ID:NP_001276674
Protein GI:576583519
UniProt ID:P04406
mRNA ID:NM_001289745
Length:335
RefSeq Status:
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTG
VFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGR
GALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAG
IALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
 
mat_peptide: 2..32
product: hGAPDH (2-32)
experiment: DESCRIPTION:antimicrobial peptide[PMID: 22832495]
calculated_mol_wt: 3187
peptide sequence: 
GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA

mat_peptide: 2..32
product: hGAPDH (2-32)
experiment: DESCRIPTION:antimicrobial peptide[PMID: 22832495]
calculated_mol_wt: 3187
peptide sequence: 
GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA
 
glyceraldehyde-3-phosphate dehydrogenase isoform 1
Refseq ID:NP_002037
Protein GI:7669492
UniProt ID:P04406
mRNA ID:NM_002046
Length:335
RefSeq Status:
Protein sequence is identical to GI:576583519 (mRNA isoform)
 
mat_peptide: 2..32
product: hGAPDH (2-32)
experiment: DESCRIPTION:antimicrobial peptide[PMID: 22832495]
calculated_mol_wt: 3187
peptide sequence: 
GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA
 
glyceraldehyde-3-phosphate dehydrogenase isoform 1
Refseq ID:NP_001276675
Protein GI:576583524
UniProt ID:P04406
mRNA ID:NM_001289746
Length:335
RefSeq Status:
Protein sequence is identical to GI:576583519 (mRNA isoform)
 
mat_peptide: 2..32
product: hGAPDH (2-32)
experiment: DESCRIPTION:antimicrobial peptide[PMID: 22832495]
calculated_mol_wt: 3187
peptide sequence: 
GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA

mat_peptide: 2..32
product: hGAPDH (2-32)
experiment: DESCRIPTION:antimicrobial peptide[PMID: 22832495]
calculated_mol_wt: 3187
peptide sequence: 
GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA

mat_peptide: 2..32
product: hGAPDH (2-32)
experiment: DESCRIPTION:antimicrobial peptide[PMID: 22832495]
calculated_mol_wt: 3187
peptide sequence: 
GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA
 
glyceraldehyde-3-phosphate dehydrogenase isoform 2
Refseq ID:NP_001243728
Protein GI:378404908
UniProt ID:P04406
mRNA ID:NM_001256799
Length:293
RefSeq Status:
MVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDN
SLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSV
VDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
 
mat_peptide: 2..32
product: hGAPDH (2-32)
experiment: DESCRIPTION:antimicrobial peptide[PMID: 22832495]
calculated_mol_wt: 3187
peptide sequence: 
GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA

mat_peptide: 2..32
product: hGAPDH (2-32)
experiment: DESCRIPTION:antimicrobial peptide[PMID: 22832495]
calculated_mol_wt: 3187
peptide sequence: 
GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA

mat_peptide: 2..32
product: hGAPDH (2-32)
experiment: DESCRIPTION:antimicrobial peptide[PMID: 22832495]
calculated_mol_wt: 3187
peptide sequence: 
GKVKVGVNGFGRIGRLVTRAAFNSGKVDIVA
 
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