MGP Database

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MGP001157

Record overview

MGPD IDMGP001157
Gene ID2618
SpeciesHomo sapiens (Human)
Gene Namephosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Gene Symbol GART
SynonymsAIRS; GARS; PAIS; PGFT; PRGS; GARTF;
Alternate namestrifunctional purine biosynthetic protein adenosine-3;
Chromosome21
Map Location21q22.11
EC Number6.3.4.13
SummaryThe protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GART

Proteins

trifunctional purine biosynthetic protein adenosine-3 isoform 1
Refseq ID:NP_001129477
Protein GI:209869993
UniProt ID:P22102
mRNA ID:NM_001136005
Length:1010
RefSeq Status:
MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQFCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEA
AQLESSKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDGEEVSC
LCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFPEAQALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISAL
EEAKKGLAAIKFEGAIYRKDVGFRAIAFLQQPRSLTYKESGVDIAAGNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKL
KIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRIYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKLGV
DLDAQTWRIPRVFSWLQQEGHLSEEEMARTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKNLIESMQINGSVLKNGSLTNH
FSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIVISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILS
GPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGE
NGKICWVKEE
 
trifunctional purine biosynthetic protein adenosine-3 isoform 1
Refseq ID:NP_000810
Protein GI:4503915
UniProt ID:P22102
mRNA ID:NM_000819
Length:1010
RefSeq Status:
Protein sequence is identical to GI:209869993 (mRNA isoform)
 
trifunctional purine biosynthetic protein adenosine-3 isoform 1
Refseq ID:NP_001129478
Protein GI:209869995
UniProt ID:P22102
mRNA ID:NM_001136006
Length:1010
RefSeq Status:
Protein sequence is identical to GI:209869993 (mRNA isoform)
 
trifunctional purine biosynthetic protein adenosine-3 isoform 2
Refseq ID:NP_780294
Protein GI:28416899
UniProt ID:P22102
mRNA ID:NM_175085
Length:433
RefSeq Status:
MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQFCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEA
AQLESSKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDGEEVSC
LCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFPEAQALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISAL
EEAKKGLAAIKFEGAIYRKDVGFRAIAFLQQPR
 
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