MGP Database

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MGP001157

UniProt Annotations

Entry Information
Gene Namephosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Protein EntryPUR2_HUMAN
UniProt IDP22102
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P22102-1; Sequence=Displayed; Name=Short; IsoId=P22102-2; Sequence=VSP_005517;
Catalytic Activity10-formyltetrahydrofolate + N(1)-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide.
Catalytic ActivityATP + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D- ribosyl)imidazole.
Catalytic ActivityATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.
PathwayPurine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide: step 2/2.
PathwayPurine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D- ribose 1-diphosphate: step 2/2.
PathwayPurine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5- phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.
SimilarityContains 1 ATP-grasp domain. {ECO:0000305}.
SimilarityIn the central section; belongs to the AIR synthase family. {ECO:0000305}.
SimilarityIn the C-terminal section; belongs to the GART family. {ECO:0000305}.
SimilarityIn the N-terminal section; belongs to the GARS family. {ECO:0000305}.
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