MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001160

UniProt Annotations

Entry Information
Gene Namegrowth arrest-specific 6
Protein EntryGAS6_HUMAN
UniProt IDQ14393
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=gas6SV; IsoId=Q14393-1; Sequence=Displayed; Name=2; IsoId=Q14393-2; Sequence=VSP_010494; Name=3; IsoId=Q14393-3; Sequence=VSP_010492, VSP_010493, VSP_010494; Note=No experimental confirmation available.; Name=4; IsoId=Q14393-4; Sequence=VSP_043832, VSP_010494; Name=5; IsoId=Q14393-5; Sequence=VSP_045685; Note=No experimental confirmation available.;
FunctionLigand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:18840707}.
InteractionP30530:AXL; NbExp=8; IntAct=EBI-2802811, EBI-2850927;
PtmGamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. {ECO:0000255|PROSITE-ProRule:PRU00463}.
PtmIsoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. {ECO:0000269|PubMed:9326369}.
SimilarityContains 1 Gla (gamma-carboxy-glutamate) domain. {ECO:0000255|PROSITE-ProRule:PRU00463}.
SimilarityContains 2 laminin G-like domains. {ECO:0000255|PROSITE-ProRule:PRU00122}.
SimilarityContains 4 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
Subcellular LocationSecreted {ECO:0000269|PubMed:9326369}.
SubunitHeterodimer and heterotetramer with AXL. {ECO:0000269|PubMed:16362042}.
Tissue SpecificityPlasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. {ECO:0000269|PubMed:8336730, ECO:0000269|PubMed:9326368}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/gas6/";
  logo