MGP Database

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MGP001195

Record overview

MGPD IDMGP001195
Gene ID2678
SpeciesHomo sapiens (Human)
Gene Namegamma-glutamyltransferase 1
Gene Symbol GGT1
SynonymsGGT; GTG; CD224; GGT 1; D22S672; D22S732;
Alternate namesgamma-glutamyltranspeptidase 1; glutathione hydrolase 1; leukotriene-C4 hydrolase;
Chromosome22
Map Location22q11.23
EC Number2.3.2.2
SummaryThe enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
OrthologsView orthologs and multiple alignments for GGT1

Proteins

gamma-glutamyltranspeptidase 1 precursor
Refseq ID:NP_001275762
Protein GI:572152963
UniProt ID:P19440
mRNA ID:NM_001288833
Length:569
RefSeq Status:
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTI
NLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVE
EPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
 
mat_peptide: 1..380
product: Gamma-glutamyltranspeptidase 1 heavy chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 41431
peptide sequence: 
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG

mat_peptide: 381..569
product: Gamma-glutamyltranspeptidase 1 light chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 19998
peptide sequence: 
TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
 
gamma-glutamyltranspeptidase 1 precursor
Refseq ID:NP_038347
Protein GI:73915092
UniProt ID:P19440
mRNA ID:NM_013430
Length:569
RefSeq Status:
Protein sequence is identical to GI:572152963 (mRNA isoform)
 
mat_peptide: 1..380
product: Gamma-glutamyltranspeptidase 1 heavy chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 41431
peptide sequence: 
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG

mat_peptide: 381..569
product: Gamma-glutamyltranspeptidase 1 light chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 19998
peptide sequence: 
TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY

mat_peptide: 1..380
product: Gamma-glutamyltranspeptidase 1 heavy chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 41431
peptide sequence: 
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG

mat_peptide: 381..569
product: Gamma-glutamyltranspeptidase 1 light chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 19998
peptide sequence: 
TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
 
gamma-glutamyltranspeptidase 1 precursor
Refseq ID:NP_038265
Protein GI:572153074
UniProt ID:P19440
mRNA ID:NM_013421
Length:569
RefSeq Status:
Protein sequence is identical to GI:572152963 (mRNA isoform)
 
mat_peptide: 1..380
product: Gamma-glutamyltranspeptidase 1 heavy chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 41431
peptide sequence: 
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG

mat_peptide: 381..569
product: Gamma-glutamyltranspeptidase 1 light chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 19998
peptide sequence: 
TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY

mat_peptide: 1..380
product: Gamma-glutamyltranspeptidase 1 heavy chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 41431
peptide sequence: 
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG

mat_peptide: 381..569
product: Gamma-glutamyltranspeptidase 1 light chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 19998
peptide sequence: 
TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY

mat_peptide: 1..380
product: Gamma-glutamyltranspeptidase 1 heavy chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 41431
peptide sequence: 
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG

mat_peptide: 381..569
product: Gamma-glutamyltranspeptidase 1 light chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 19998
peptide sequence: 
TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
 
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