MGP Database

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MGP001195

Ontology/Pathway Information

Entrez Gene ID2678
Gene Namegamma-glutamyltransferase 1
Gene Symbol GGT1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031362 TAS:UniProtKBCanchored component of external side of plasma membrane
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0003840 IDA:UniProtKBFgamma-glutamyltransferase activity
GO:0036374 IDA:UniProtKBFglutathione hydrolase activity
GO:0019369 TAS:ReactomeParachidonic acid metabolic process
GO:0006520 TAS:ProtIncPcellular amino acid metabolic process
GO:0019344 ISS:UniProtKBPcysteine biosynthetic process
GO:0006536 IDA:UniProtKBPglutamate metabolic process
GO:0006750 ISS:UniProtKBPglutathione biosynthetic process
GO:0006751 IDA:UniProtKBPglutathione catabolic process
GO:1901687 TAS:ReactomePglutathione derivative biosynthetic process
GO:0006749 TAS:UniProtKBPglutathione metabolic process
GO:0019370 IMP:UniProtKBPleukotriene biosynthetic process
GO:0006691 TAS:ReactomePleukotriene metabolic process
GO:0002682 ISS:UniProtKBPregulation of immune system process
GO:0050727 ISS:UniProtKBPregulation of inflammatory response
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007283 ISS:UniProtKBPspermatogenesis
GO:0006805 TAS:ReactomePxenobiotic metabolic process
GO:0031638 IDA:UniProtKBPzymogen activation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264461Aflatoxin activation and detoxification
REACT_147851Arachidonic acid metabolism
REACT_13433Biological oxidations
REACT_267633Defective ACY1 causes encephalopathy
REACT_268587Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058Defective UGT1A1 causes hyperbilirubinemia
REACT_268618Defective UGT1A4 causes hyperbilirubinemia
REACT_116125Disease
REACT_6926Glutathione conjugation
REACT_6960Glutathione synthesis and recycling
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_6959Phase II conjugation
REACT_150420Synthesis of Leukotrienes (LT) and Eoxins (EX)
SMP Pathway Links
SMP IDDescription
SMP00710Acetaminophen Action Pathway
SMP00083Acetylsalicylic Acid Action Pathway
SMP00692Antipyrine Action Pathway
SMP00693Antrafenine Action Pathway
SMP00075Arachidonic Acid Metabolism
SMP00102Bromfenac Action Pathway
SMP00694Carprofen Action Pathway
SMP00096Celecoxib Action Pathway
SMP00093Diclofenac Action Pathway
SMP00289Diflunisal Action Pathway
SMP00084Etodolac Action Pathway
SMP00695Etoricoxib Action Pathway
SMP00696Fenoprofen Action Pathway
SMP00697Flurbiprofen Action Pathway
SMP00086Ibuprofen Action Pathway
SMP00104Indomethacin Action Pathway
SMP00085Ketoprofen Action Pathway
SMP00098Ketorolac Action Pathway
SMP00353Leukotriene C4 Synthesis Deficiency
SMP00700Lornoxicam Action Pathway
SMP00699Lumiracoxib Action Pathway
SMP00698Magnesium salicylate Action Pathway
SMP00109Mefenamic Acid Action Pathway
SMP00106Meloxicam Action Pathway
SMP00114Nabumetone Action Pathway
SMP00120Naproxen Action Pathway
SMP00702Nepafenac Action Pathway
SMP00113Oxaprozin Action Pathway
SMP00701Phenylbutazone Action Pathway
SMP00077Piroxicam Action Pathway
SMP00087Rofecoxib Action Pathway
SMP00708Salicylate-sodium Action Pathway
SMP00709Salicylic Acid Action Pathway
SMP00707Salsalate Action Pathway
SMP00029Selenoamino Acid Metabolism
SMP00094Sulindac Action Pathway
SMP00101Suprofen Action Pathway
SMP00706Tenoxicam Action Pathway
SMP00705Tiaprofenic Acid Action Pathway
SMP00704Tolmetin Action Pathway
SMP00703Trisalicylate-choline Action Pathway
SMP00116Valdecoxib Action Pathway
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