MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001198

UniProt Annotations

Entry Information
Gene Namegamma-glutamyltransferase 5
Protein EntryGGT5_HUMAN
UniProt IDP36269
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P36269-1; Sequence=Displayed; Name=2; IsoId=P36269-2; Sequence=VSP_008146; Note=No experimental confirmation available.; Name=3; IsoId=P36269-3; Sequence=VSP_043470; Note=No experimental confirmation available.;
Catalytic ActivityA (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Catalytic ActivityGlutathione + H(2)O = L-cysteinylglycine + L- glutamate.
Catalytic ActivityLeukotriene C(4) + H(2)O = leukotriene D(4) + L-glutamate.
FunctionCleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).
PathwayLipid metabolism; leukotriene D4 biosynthesis.
PathwaySulfur metabolism; glutathione metabolism.
PtmCleaved by autocatalysis into a large and a small subunit. {ECO:0000250}.
Sequence CautionSequence=CAB55910.1; Type=Frameshift; Positions=446; Evidence={ECO:0000305};
SimilarityBelongs to the gamma-glutamyltransferase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
SubunitHeterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). {ECO:0000250}.
  logo