MGP Database

MGP001208

Ontology/Pathway Information

Entrez Gene ID	2697
Gene Name	gap junction protein, alpha 1, 43kDa
Gene Symbol	GJA1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016324	IEA:Ensembl	C	apical plasma membrane
GO:0005922	TAS:ProtInc	C	connexon complex
GO:0043292	IEA:Ensembl	C	contractile fiber
GO:0005829	IEA:Ensembl	C	cytosol
GO:0005769	IEA:Ensembl	C	early endosome
GO:0005789	TAS:Reactome	C	endoplasmic reticulum membrane
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005916	IEA:Ensembl	C	fascia adherens
GO:0005925	IDA:UniProtKB	C	focal adhesion
GO:0005921	IDA:BHF-UCL	C	gap junction
GO:0005794	ISS:BHF-UCL	C	Golgi apparatus
GO:0030660	TAS:Reactome	C	Golgi-associated vesicle membrane
GO:0000139	TAS:Reactome	C	Golgi membrane
GO:0005887	TAS:UniProtKB	C	integral component of plasma membrane
GO:0014704	IDA:BHF-UCL	C	intercalated disc
GO:0005882	IEA:Ensembl	C	intermediate filament
GO:0016328	IEA:Ensembl	C	lateral plasma membrane
GO:0005764	IEA:Ensembl	C	lysosome
GO:0045121	ISS:BHF-UCL	C	membrane raft
GO:0005741	IEA:Ensembl	C	mitochondrial outer membrane
GO:0005771	IEA:Ensembl	C	multivesicular body
GO:0005886	ISS:BHF-UCL	C	plasma membrane
GO:0005243	IDA:BHF-UCL	F	gap junction channel activity
GO:0015075	TAS:ProtInc	F	ion transmembrane transporter activity
GO:0004871	IMP:UniProtKB	F	signal transducer activity
GO:0007512	IEA:Ensembl	P	adult heart development
GO:0006915	IEA:Ensembl	P	apoptotic process
GO:0015867	IEA:Ensembl	P	ATP transport
GO:0086014	TAS:BHF-UCL	P	atrial cardiac muscle cell action potential
GO:0003294	IEA:Ensembl	P	atrial ventricular junction remodeling
GO:0048514	IEA:Ensembl	P	blood vessel morphogenesis
GO:0007267	TAS:ProtInc	P	cell-cell signaling
GO:0010643	IEA:Ensembl	P	cell communication by chemical coupling
GO:0010644	IDA:BHF-UCL	P	cell communication by electrical coupling
GO:0071260	IEA:Ensembl	P	cellular response to mechanical stimulus
GO:0002544	IEA:Ensembl	P	chronic inflammatory response
GO:0042733	IEA:Ensembl	P	embryonic digit morphogenesis
GO:0003158	IEA:Ensembl	P	endothelium development
GO:0002070	IEA:Ensembl	P	epithelial cell maturation
GO:0016264	TAS:UniProtKB	P	gap junction assembly
GO:0007507	TAS:ProtInc	P	heart development
GO:0001947	IEA:Ensembl	P	heart looping
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0034220	TAS:GOC	P	ion transmembrane transport
GO:0002088	IEA:Ensembl	P	lens development in camera-type eye
GO:0061024	TAS:Reactome	P	membrane organization
GO:0060156	IEA:Ensembl	P	milk ejection
GO:0006936	TAS:ProtInc	P	muscle contraction
GO:0060044	IEA:Ensembl	P	negative regulation of cardiac muscle cell proliferation
GO:2000279	IEA:Ensembl	P	negative regulation of DNA biosynthetic process
GO:0001937	IEA:Ensembl	P	negative regulation of endothelial cell proliferation
GO:0010629	IEA:Ensembl	P	negative regulation of gene expression
GO:0061045	IEA:Ensembl	P	negative regulation of wound healing
GO:0001764	IEA:Ensembl	P	neuron migration
GO:0048812	IEA:Ensembl	P	neuron projection morphogenesis
GO:0001649	IEA:Ensembl	P	osteoblast differentiation
GO:2000987	IEA:Ensembl	P	positive regulation of behavioral fear response
GO:0010652	IEA:Ensembl	P	positive regulation of cell communication by chemical coupling
GO:0007204	IEA:Ensembl	P	positive regulation of cytosolic calcium ion concentration
GO:0010628	IEA:Ensembl	P	positive regulation of gene expression
GO:0003104	IEA:Ensembl	P	positive regulation of glomerular filtration
GO:0043123	IMP:UniProtKB	P	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032024	IEA:Ensembl	P	positive regulation of insulin secretion
GO:0045732	IEA:Ensembl	P	positive regulation of protein catabolic process
GO:0045844	IEA:Ensembl	P	positive regulation of striated muscle tissue development
GO:0045907	IEA:Ensembl	P	positive regulation of vasoconstriction
GO:0045909	IEA:Ensembl	P	positive regulation of vasodilation
GO:0051259	IEA:Ensembl	P	protein oligomerization
GO:0060371	IEA:Ensembl	P	regulation of atrial cardiac muscle cell membrane depolarization
GO:0030500	IEA:Ensembl	P	regulation of bone mineralization
GO:0046850	IEA:Ensembl	P	regulation of bone remodeling
GO:0051924	IEA:Ensembl	P	regulation of calcium ion transport
GO:2000810	IEA:Ensembl	P	regulation of tight junction assembly
GO:0060373	IEA:Ensembl	P	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060307	IEA:Ensembl	P	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0034405	IEA:Ensembl	P	response to fluid shear stress
GO:0009749	IEA:Ensembl	P	response to glucose
GO:0043434	IEA:Ensembl	P	response to peptide hormone
GO:0009268	IEA:Ensembl	P	response to pH
GO:0007165	IMP:GOC	P	signal transduction
GO:0043403	IEA:Ensembl	P	skeletal muscle tissue regeneration
GO:0006810	TAS:ProtInc	P	transport
GO:0010232	IEA:Ensembl	P	vascular transport

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_11043	c-src mediated regulation of Cx43 function and closure of gap junctions
REACT_11049	Formation of annular gap junctions
REACT_9509	Gap junction assembly
REACT_11035	Gap junction degradation
REACT_9411	Gap junction trafficking
REACT_9480	Gap junction trafficking and regulation
REACT_11123	Membrane Trafficking
REACT_11039	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
REACT_9398	Oligomerization of connexins into connexons
REACT_11034	Regulation of gap junction activity
REACT_9392	Transport of connexins along the secretory pathway
REACT_11050	Transport of connexons to the plasma membrane