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MGP001239

Record overview

MGPD IDMGP001239
Gene ID2762
SpeciesHomo sapiens (Human)
Gene NameGDP-mannose 4,6-dehydratase
Gene Symbol GMDS
SynonymsGMD; SDR3E1;
Alternate namesGDP-mannose 4,6 dehydratase; GDP-D-mannose dehydratase; short chain dehydrogenase/reductase family 3E, member 1;
Chromosome6
Map Location6p25
EC Number4.2.1.47
SummaryGDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
OrthologsView orthologs and multiple alignments for GMDS

Proteins

GDP-mannose 4,6 dehydratase isoform 1
Refseq ID:NP_001491
Protein GI:4504031
UniProt ID:O60547
mRNA ID:NM_001500
Length:372
RefSeq Status:
MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEV
KPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLF
AVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA
 
GDP-mannose 4,6 dehydratase isoform 2
Refseq ID:NP_001240775
Protein GI:359718934
UniProt ID:O60547
mRNA ID:NM_001253846
Length:342
RefSeq Status:
MCKMDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGV
GTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKI
YLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVD
FLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA
 
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