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MGP001239

UniProt Annotations

Entry Information
Gene NameGDP-mannose 4,6-dehydratase
Protein EntryGMDS_HUMAN
UniProt IDO60547
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60547-1; Sequence=Displayed; Name=2; IsoId=O60547-2; Sequence=VSP_047324; Note=No experimental confirmation available.;
Catalytic ActivityGDP-alpha-D-mannose = GDP-4-dehydro-alpha-D- rhamnose + H(2)O.
CofactorName=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000269|Ref.8};
FunctionCatalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose.
PathwayNucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.
Sequence CautionSequence=AAC24501.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. {ECO:0000305}.
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