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MGP001244

UniProt Annotations

Entry Information
Gene Nameguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Protein EntryGNAI1_HUMAN
UniProt IDP63096
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P63096-1; Sequence=Displayed; Name=2; IsoId=P63096-2; Sequence=VSP_045215;
FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. {ECO:0000269|PubMed:17264214, ECO:0000269|PubMed:17635935}.
InteractionP81274:GPSM2; NbExp=3; IntAct=EBI-618639, EBI-618655; Q14980:NUMA1; NbExp=4; IntAct=EBI-618639, EBI-521611;
SimilarityBelongs to the G-alpha family. G(i/o/t/z) subfamily. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Note=Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. {ECO:0000250}.
SubunitInteracts with GPSM1. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains); the interaction occurs in the centrosomes. Interacts (GDP-bound form) with RIC8A (via C-terminus) (By similarity). Interacts with DRD2. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. {ECO:0000250, ECO:0000269|PubMed:11976690, ECO:0000269|PubMed:16004878, ECO:0000269|PubMed:17264214, ECO:0000269|PubMed:21115486}.
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