MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001254

UniProt Annotations

Entry Information
Gene Nameguanine nucleotide binding protein (G protein), beta polypeptide 1
Protein EntryGBB1_HUMAN
UniProt IDP62873
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P62873-1; Sequence=Displayed; Name=2; IsoId=P62873-2; Sequence=VSP_055232; Note=No experimental confirmation available.;
FunctionGuanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. {ECO:0000269|PubMed:18611381}.
InteractionP19878:NCF2; NbExp=2; IntAct=EBI-357130, EBI-489611;
PtmPhosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP. {ECO:0000250}.
SimilarityBelongs to the WD repeat G protein beta family. {ECO:0000305}.
SimilarityContains 7 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
SubunitG proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus). {ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:18611381, ECO:0000269|PubMed:19255495}.
  logo