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MGP001271

UniProt Annotations

Entry Information
Gene Nameglutamic-oxaloacetic transaminase 2, mitochondrial
Protein EntryAATM_HUMAN
UniProt IDP00505
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P00505-1; Sequence=Displayed; Name=2; IsoId=P00505-2; Sequence=VSP_054848;
Catalytic ActivityL-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Catalytic ActivityL-kynurenine + 2-oxoglutarate = 4-(2- aminophenyl)-2,4-dioxobutanoate + L-glutamate.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
FunctionCatalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:9537447}.
InductionUp-regulated by long-time exposure to alcohol. {ECO:0000269|PubMed:9537447}.
MiscellaneousIn eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
SimilarityBelongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:9537447}. Cell membrane {ECO:0000269|PubMed:9537447}. Note=Exposure to alcohol promotes translocation to the cell membrane.
SubunitHomodimer.
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