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MGP001272

UniProt Annotations

Entry Information
Gene Namestratifin
Protein Entry1433S_HUMAN
UniProt IDP31947
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31947-1; Sequence=Displayed; Name=2; IsoId=P31947-2; Sequence=VSP_021768; Note=No experimental confirmation available.;
FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269|PubMed:18382127}.
Functionp53-regulated inhibitor of G2/M progression. {ECO:0000269|PubMed:18382127}.
InteractionP00519:ABL1; NbExp=2; IntAct=EBI-476295, EBI-375543; Q96IF1:AJUBA; NbExp=2; IntAct=EBI-476295, EBI-949782; Q92934:BAD; NbExp=4; IntAct=EBI-476295, EBI-700771; Q7L5N1:COPS6; NbExp=7; IntAct=EBI-476295, EBI-486838; P00533:EGFR; NbExp=8; IntAct=EBI-476295, EBI-297353; Q9UJM3:ERRFI1; NbExp=3; IntAct=EBI-476295, EBI-2941912; O60269:GPRIN2; NbExp=2; IntAct=EBI-476295, EBI-740397; P56524:HDAC4; NbExp=4; IntAct=EBI-476295, EBI-308629; Q9UQL6:HDAC5; NbExp=3; IntAct=EBI-476295, EBI-715576; Q8WUI4:HDAC7; NbExp=3; IntAct=EBI-476295, EBI-1048378; Q14103-4:HNRNPD; NbExp=7; IntAct=EBI-476295, EBI-432545; P27448:MARK3; NbExp=2; IntAct=EBI-476295, EBI-707595; O00444:PLK4; NbExp=2; IntAct=EBI-476295, EBI-746202; P04049:RAF1; NbExp=2; IntAct=EBI-476295, EBI-365996; Q8NFH8-2:REPS2; NbExp=2; IntAct=EBI-476295, EBI-8029141; Q8NHY2:RFWD2; NbExp=6; IntAct=EBI-476295, EBI-1176214; P04637:TP53; NbExp=4; IntAct=EBI-476295, EBI-366083; P63104:YWHAZ; NbExp=2; IntAct=EBI-476295, EBI-347088;
PtmUbiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. {ECO:0000269|PubMed:18382127}.
SimilarityBelongs to the 14-3-3 family. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
SubunitHomodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with RFWD2; this interaction leads to proteasomal degradation. {ECO:0000250, ECO:0000269|PubMed:15282546, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:19172738, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:22634725}.
Tissue SpecificityPresent mainly in tissues enriched in stratified squamous keratinizing epithelium.
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