MGP Database

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MGP001280

UniProt Annotations

Entry Information
Gene Nameglucose-6-phosphate isomerase
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06744-1; Sequence=Displayed; Name=2; IsoId=P06744-2; Sequence=VSP_043475, VSP_043476; Note=No experimental confirmation available.;
Catalytic ActivityD-glucose 6-phosphate = D-fructose 6- phosphate.
DiseaseHemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID) [MIM:613470]: A form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionBesides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381}.
PathwayCarbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 2/4.
PtmISGylated. {ECO:0000269|PubMed:16139798}.
PtmPhosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non- classical secretory pathway. {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:15637053, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332}.
SimilarityBelongs to the GPI family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:11437381}. Secreted {ECO:0000269|PubMed:11437381}.
SubunitHomodimer in the catalytically active form, monomer in the secreted form. {ECO:0000269|PubMed:11371164, ECO:0000269|PubMed:12054796, ECO:0000269|PubMed:12777791}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpi/";
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GPI";
Web ResourceName=Wikipedia; Note=Phosphoglucose isomerase entry; URL="http://en.wikipedia.org/wiki/Phosphoglucose_isomerase";
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