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MGP001309

Record overview

MGPD IDMGP001309
Gene ID2886
SpeciesHomo sapiens (Human)
Gene Namegrowth factor receptor-bound protein 7
Gene Symbol GRB7
Alternate namesgrowth factor receptor-bound protein 7; B47; GRB7 adapter protein; epidermal growth factor receptor GRB-7;
Chromosome17
Map Location17q12
SummaryThe product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
OrthologsView orthologs and multiple alignments for GRB7

Proteins

growth factor receptor-bound protein 7 isoform a
Refseq ID:NP_001229372
Protein GI:334883161
UniProt ID:Q14451
mRNA ID:NM_001242443
Length:532
RefSeq Status:
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASR
PHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFP
EKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG
FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQ
AWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQT
RFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
 
growth factor receptor-bound protein 7 isoform a
Refseq ID:NP_001025173
Protein GI:71979667
UniProt ID:Q14451
mRNA ID:NM_001030002
Length:532
RefSeq Status:
Protein sequence is identical to GI:334883161 (mRNA isoform)
 
growth factor receptor-bound protein 7 isoform a
Refseq ID:NP_005301
Protein GI:71979665
UniProt ID:Q14451
mRNA ID:NM_005310
Length:532
RefSeq Status:
Protein sequence is identical to GI:334883161 (mRNA isoform)
 
growth factor receptor-bound protein 7 isoform b
Refseq ID:NP_001229371
Protein GI:334883159
UniProt ID:Q14451
mRNA ID:NM_001242442
Length:555
RefSeq Status:
MGKWRPGQGHTTGSVKPLSRSDAMELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSP
PSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDS
RFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVAD
VNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDF
SGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKV
KHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
 
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