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MGP001309

UniProt Annotations

Entry Information
Gene Namegrowth factor receptor-bound protein 7
Protein EntryGRB7_HUMAN
UniProt IDQ14451
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Comment=At least 2 isoforms are produced.; Name=1; IsoId=Q14451-1; Sequence=Displayed; Name=2; Synonyms=Grb7V; IsoId=Q14451-2; Sequence=VSP_035500, VSP_035501; Name=3; IsoId=Q14451-3; Sequence=VSP_041665; Note=Ref.5 (BAG54211) sequence is in conflict in position: 20:C->R. {ECO:0000305}; Name=4; IsoId=Q14451-4; Sequence=VSP_041666;
DomainThe PH domain mediates interaction with membranes containing phosphoinositides. {ECO:0000269|PubMed:12021278}.
FunctionAdapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250}.
InteractionSelf; NbExp=2; IntAct=EBI-970191, EBI-970191; P10275:AR; NbExp=3; IntAct=EBI-970191, EBI-608057; P62157:CALM (xeno); NbExp=2; IntAct=EBI-970191, EBI-397403; P62161:Calm3 (xeno); NbExp=9; IntAct=EBI-970191, EBI-397530; P54762:EPHB1; NbExp=4; IntAct=EBI-970191, EBI-80252; P04626:ERBB2; NbExp=5; IntAct=EBI-970191, EBI-641062; P21860:ERBB3; NbExp=7; IntAct=EBI-970191, EBI-720706; O00165:HAX1; NbExp=2; IntAct=EBI-970191, EBI-357001; P10721:KIT; NbExp=4; IntAct=EBI-970191, EBI-1379503; P09619:PDGFRB; NbExp=4; IntAct=EBI-970191, EBI-641237; Q92730:RND1; NbExp=4; IntAct=EBI-970191, EBI-448618;
PtmPhosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down- stream protein kinases. {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19473962, ECO:0000269|PubMed:20622016}.
SimilarityBelongs to the GRB7/10/14 family. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 Ras-associating domain. {ECO:0000255|PROSITE-ProRule:PRU00166}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular LocationCytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule {ECO:0000250}. Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions (By similarity). {ECO:0000250}.
SubunitHomodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). {ECO:0000250}.
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