MGP Database

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MGP001314

UniProt Annotations

Entry Information
Gene Nameglutamate receptor, ionotropic, AMPA 2
Protein EntryGRIA2_HUMAN
UniProt IDP42262
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=Flop; IsoId=P42262-1; Sequence=Displayed; Name=Flip; IsoId=P42262-2; Sequence=VSP_053350; Name=3; Synonyms=Long; IsoId=P42262-3; Sequence=VSP_029309; Name=4; IsoId=P42262-4; Sequence=VSP_055920, VSP_053350; Note=No experimental confirmation available.;
DomainThe M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
FunctionReceptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20614889}.
InteractionP46459:NSF; NbExp=2; IntAct=EBI-3909876, EBI-712251;
MiscellaneousThe postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
PtmPalmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). {ECO:0000250}.
Rna EditingModified_positions=607 {ECO:0000269|PubMed:7523595}; Note=Partially edited. Fully edited in the brain. Heteromerically expressed edited GLUR2 (R) receptor complexes are impermeable to calcium, whereas the unedited (Q) forms are highly permeable to divalent ions.;
SimilarityBelongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.
SubunitHomotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1- catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly (By similarity). Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2 (By similarity). Interacts with GRIA1 and SYNDIG1 (By similarity). Interacts with LRFN1. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By similarity). {ECO:0000250}.
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