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MGP001338

UniProt Annotations

Entry Information
Gene Namechemokine (C-X-C motif) ligand 3
Protein EntryCXCL3_HUMAN
UniProt IDP19876
SpeciesHuman
Comments
Comment typeDescription
FunctionLigand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. {ECO:0000250, ECO:0000269|PubMed:10095777}.
PtmN-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes. {ECO:0000269|PubMed:10095777}.
SimilarityBelongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
Subcellular LocationSecreted.
Web ResourceName=Wikipedia; Note=CXCL3 entry; URL="http://en.wikipedia.org/wiki/CXCL3";
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