MGP Database

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MGP001340

Ontology/Pathway Information

Entrez Gene ID2923
Gene Nameprotein disulfide isomerase family A, member 3
Gene Symbol PDIA3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:MGICcell surface
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0005788 TAS:ReactomeCendoplasmic reticulum lumen
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0042470 IEA:UniProtKB-SubCellCmelanosome
GO:0005634 IDA:UniProtKBCnucleus
GO:0005790 IEA:EnsemblCsmooth endoplasmic reticulum
GO:0004197 TAS:ProtIncFcysteine-type endopeptidase activity
GO:0004629 TAS:ProtIncFphospholipase C activity
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0003756 IBA:GO_CentralFprotein disulfide isomerase activity
GO:0042590 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474 TAS:ReactomePantigen processing and presentation of peptide antigen via MHC class I
GO:0045454 IEA:InterProPcell redox homeostasis
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:2001238 IEA:EnsemblPpositive regulation of extrinsic apoptotic signaling pathway
GO:0043687 TAS:ReactomePpost-translational protein modification
GO:0006457 IBA:GO_CentralPprotein folding
GO:0006606 TAS:ProtIncPprotein import into nucleus
GO:0018279 TAS:ReactomePprotein N-linked glycosylation via asparagine
GO:0006621 TAS:ProtIncPprotein retention in ER lumen
GO:0006508 TAS:GOCPproteolysis
GO:0034976 IBA:GO_CentralPresponse to endoplasmic reticulum stress
GO:0007165 TAS:ProtIncPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_75795Antigen Presentation: Folding, assembly and peptide loading of class I MHC
REACT_111119Antigen processing-Cross presentation
REACT_22426Asparagine N-linked glycosylation
REACT_23810Calnexin/calreticulin cycle
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_268132Defective ALG11 causes ALG11-CDG (CDG-1p)
REACT_267773Defective ALG12 causes ALG12-CDG (CDG-1g)
REACT_268645Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
REACT_268144Defective ALG1 causes ALG1-CDG (CDG-1k)
REACT_268833Defective ALG2 causes ALG2-CDG (CDG-1i)
REACT_268185Defective ALG3 causes ALG3-CDG (CDG-1d)
REACT_267765Defective ALG6 causes ALG6-CDG (CDG-1c)
REACT_268459Defective ALG8 causes ALG8-CDG (CDG-1h)
REACT_268015Defective ALG9 causes ALG9-CDG (CDG-1l)
REACT_268438Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
REACT_268849Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
REACT_268813Defective MAN1B1 causes MRT15
REACT_268600Defective MGAT2 causes MGAT2-CDG (CDG-2a)
REACT_267905Defective MOGS causes MOGS-CDG (CDG-2b)
REACT_268619Defective MPDU1 causes MPDU1-CDG (CDG-1f)
REACT_268458Defective RFT1 causes RFT1-CDG (CDG-1n)
REACT_116125Disease
REACT_267875Diseases associated with N-glycosylation of proteins
REACT_268324Diseases of glycosylation
REACT_111178ER-Phagosome pathway
REACT_6900Immune System
REACT_17015Metabolism of proteins
REACT_23878N-glycan trimming in the ER and Calnexin/Calreticulin cycle
REACT_22161Post-translational protein modification
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