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MGP001340

UniProt Annotations

Entry Information
Gene Nameprotein disulfide isomerase family A, member 3
Protein EntryPDIA3_HUMAN
UniProt IDP30101
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCatalyzes the rearrangement of -S-S- bonds in proteins. {ECO:0000269|PubMed:7487104}.
CautionWas originally thought to be a phosphatidylinositol 4,5- bisphosphate phosphodiesterase type I (phospholipase C-alpha). {ECO:0000305}.
InteractionP05067:APP; NbExp=3; IntAct=EBI-979862, EBI-77613; P18418:Calr (xeno); NbExp=2; IntAct=EBI-979862, EBI-916742; Q96HE7:ERO1L; NbExp=3; IntAct=EBI-979862, EBI-2564539; Q86YB8:ERO1LB; NbExp=2; IntAct=EBI-979862, EBI-2806988; Q13162:PRDX4; NbExp=2; IntAct=EBI-979862, EBI-2211957; Q13586:STIM1; NbExp=3; IntAct=EBI-979862, EBI-448878; Q03518:TAP1; NbExp=4; IntAct=EBI-979862, EBI-747259;
Mass SpectrometryMass=54265.22; Method=MALDI; Range=25-505; Evidence={ECO:0000269|PubMed:11840567};
SimilarityBelongs to the protein disulfide isomerase family. {ECO:0000305}.
SimilarityContains 2 thioredoxin domains. {ECO:0000255|PROSITE- ProRule:PRU00691}.
Subcellular LocationEndoplasmic reticulum. Endoplasmic reticulum lumen {ECO:0000250}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitSubunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX. Interacts with SERPINA2 and with the S and Z variants of SERPINA1. {ECO:0000269|PubMed:16905107, ECO:0000269|PubMed:16940051, ECO:0000269|PubMed:19119025, ECO:0000269|PubMed:23826168}.
Tissue SpecificityDetected in the flagellum and head region of spermatozoa (at protein level). {ECO:0000269|PubMed:20400973}.
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