MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001343

Ontology/Pathway Information

Entrez Gene ID2931
Gene Nameglycogen synthase kinase 3 alpha
Gene Symbol GSK3A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030877 TAS:UniProtKBCbeta-catenin destruction complex
GO:0005829 TAS:BHF-UCLCcytosol
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0034236 IPI:BHF-UCLFprotein kinase A catalytic subunit binding
GO:0004674 IDA:BHF-UCLFprotein serine/threonine kinase activity
GO:0050321 TAS:UniProtKBFtau-protein kinase activity
GO:0006987 TAS:ReactomePactivation of signaling protein activity involved in unfolded protein response
GO:0003214 ISS:BHF-UCLPcardiac left ventricle morphogenesis
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0032869 IMP:BHF-UCLPcellular response to insulin stimulus
GO:0036016 ISS:UniProtKBPcellular response to interleukin-3
GO:0030968 TAS:ReactomePendoplasmic reticulum unfolded protein response
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0097192 ISS:UniProtKBPextrinsic apoptotic signaling pathway in absence of ligand
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0005977 IEA:UniProtKB-KWPglycogen metabolic process
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 ISS:BHF-UCLPinsulin receptor signaling pathway
GO:0090090 TAS:UniProtKBPnegative regulation of canonical Wnt signaling pathway
GO:0061052 ISS:BHF-UCLPnegative regulation of cell growth involved in cardiac muscle cell development
GO:0046325 IMP:BHF-UCLPnegative regulation of glucose import
GO:0045719 TAS:UniProtKBPnegative regulation of glycogen biosynthetic process
GO:2000466 TAS:UniProtKBPnegative regulation of glycogen (starch) synthase activity
GO:0046627 IMP:BHF-UCLPnegative regulation of insulin receptor signaling pathway
GO:0032007 ISS:BHF-UCLPnegative regulation of TOR signaling
GO:0051348 IMP:BHF-UCLPnegative regulation of transferase activity
GO:2000077 TAS:UniProtKBPnegative regulation of type B pancreatic cell development
GO:0010905 IC:UniProtKBPnegative regulation of UDP-glucose catabolic process
GO:0007399 IEA:UniProtKB-KWPnervous system development
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0071879 ISS:BHF-UCLPpositive regulation of adrenergic receptor signaling pathway
GO:0030819 ISS:BHF-UCLPpositive regulation of cAMP biosynthetic process
GO:2000467 ISS:BHF-UCLPpositive regulation of glycogen (starch) synthase activity
GO:0045823 ISS:BHF-UCLPpositive regulation of heart contraction
GO:1901030 ISS:UniProtKBPpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0045732 NAS:BHF-UCLPpositive regulation of protein catabolic process
GO:0043161 ISS:UniProtKBPproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006468 IDA:BHF-UCLPprotein phosphorylation
GO:0003073 ISS:BHF-UCLPregulation of systemic arterial blood pressure
GO:0016055 IEA:UniProtKB-KWPWnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_12564AKT phosphorylates targets in the cytosol
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_18368IRE1alpha activates chaperones
REACT_17015Metabolism of proteins
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_18356Unfolded Protein Response (UPR)
REACT_18273XBP1(S) activates chaperone genes
  logo