MGP Database

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MGP001347

Ontology/Pathway Information

Entrez Gene ID2937
Gene Nameglutathione synthetase
Gene Symbol GSS
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005524 IDA:UniProtKBFATP binding
GO:0043295 IDA:UniProtKBFglutathione binding
GO:0004363 TAS:ReactomeFglutathione synthase activity
GO:0016594 IEA:EnsemblFglycine binding
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0007568 IEA:EnsemblPaging
GO:0006520 TAS:ProtIncPcellular amino acid metabolic process
GO:0006750 TAS:ReactomePglutathione biosynthetic process
GO:1901687 TAS:ReactomePglutathione derivative biosynthetic process
GO:0007399 TAS:ProtIncPnervous system development
GO:0043200 IEA:EnsemblPresponse to amino acid
GO:0046686 IEA:EnsemblPresponse to cadmium ion
GO:0031667 IEA:EnsemblPresponse to nutrient levels
GO:0006979 TAS:ProtIncPresponse to oxidative stress
GO:0034612 IEA:EnsemblPresponse to tumor necrosis factor
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_268587Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058Defective UGT1A1 causes hyperbilirubinemia
REACT_268618Defective UGT1A4 causes hyperbilirubinemia
REACT_116125Disease
REACT_6926Glutathione conjugation
REACT_6960Glutathione synthesis and recycling
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_6959Phase II conjugation
SMP Pathway Links
SMP IDDescription
SMP001362-Hydroxyglutric Aciduria (D And L Form)
SMP002434-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
SMP005005-oxoprolinase deficiency
SMP001435-Oxoprolinuria
SMP00183Gamma-Glutamyltransferase Deficiency
SMP00501Gamma-glutamyl-transpeptidase deficiency
SMP00072Glutamate Metabolism
SMP00015Glutathione Metabolism
SMP00337Glutathione Synthetase Deficiency
SMP00385Homocarnosinosis
SMP00339Hyperinsulinism-Hyperammonemia Syndrome
SMP00567Succinic semialdehyde dehydrogenase deficiency
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