MGP Database

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MGP001348

UniProt Annotations

Entry Information
Gene Nameglutathione S-transferase alpha 1
Protein EntryGSTA1_HUMAN
UniProt IDP08263
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityRX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:20606271}.
DomainThe C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.
FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000269|PubMed:20606271}.
SimilarityBelongs to the GST superfamily. Alpha family. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer or heterodimer of GSTA1 and GSTA2. {ECO:0000269|PubMed:12211029, ECO:0000269|PubMed:15333749, ECO:0000269|PubMed:15893769, ECO:0000269|PubMed:16421451, ECO:0000269|PubMed:19618965, ECO:0000269|PubMed:20606271, ECO:0000269|PubMed:8331657, ECO:0000269|PubMed:8591048}.
Tissue SpecificityLiver.
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